Mama-Match
Sesame review
Brand only: Wegovy pill from about $149/mo, Zepbound about $349–$499/mo, with a real video visit — pricier and with more moving parts than a flat compounded plan, but transparent.
- Ask about HSA/FSA
- Independently scored
- Confirm total cost
Referral link, separate from the score
Our medical guides link to published research and official medication information. Provider reviews compare published costs and terms. These source checks do not replace clinical review or advice from your healthcare professional.
Sesame at a glance
- Semaglutide
- Brand only (Wegovy pill from ~$149/mo)
- Tirzepatide
- Brand only (Zepbound ~$349–$499/mo)
- Coverage
- All 50 states
- Brand-name
- Yes
How we scored Sesame
The Mama-Match Score of 83/100 for Sesame combines six editorial assessments using the same weighted six-factor framework we apply to every provider. It is not a clinical quality rating. A recent source check does not mean every factor was rescored; read the published terms and the methodology alongside the number. Referral payments do not change the score.
Considers the intake steps, payment timing and information available before enrollment.
Considers the full treatment cost, introductory offers and billing commitments.
Considers the described clinical team, appointment access and ways to contact a prescriber.
Considers published state coverage and treatment-specific eligibility limits.
Considers follow-up appointments, refill reviews and access to ongoing clinical support.
Considers cancellation deadlines, refund limits and prepaid commitments.
How we verified this review
- Last reviewed
- August 2026
- Confidence
- Medium
- Primary sources
Company website
Brand only: Sesame left compounded GLP-1s behind in 2025, so today it sells the Wegovy pill from around $149 and Zepbound between $349 and $499. The subscription from $59 a month is billed separately from the medication, so that's two lines rather than one.
We may earn a commission if you sign up through this link.
What to expect when you sign up
We walked Sesame's public signup (July 2026) — a first-hand look at the process. We did not create accounts, enter medical information, or complete checkout, so this is what any visitor sees, not a patient's outcome.
- 1Browse the 'Success by Sesame' weight-loss program — the platform subscription is listed from $59/mo on an annual plan (around $99/mo on a shorter 28-day cycle)
- 2The subscription covers video visits, labs, and messaging; the medication itself is billed separately from the membership
- 3You book a licensed clinician for a real video visit, rather than just an asynchronous questionnaire
- 4Brand-name options (Wegovy pill, Ozempic, Zepbound, Mounjaro, Rybelsus) are shown with cash-pay estimates before you commit
What we noticed
- Sesame stopped selling compounded semaglutide in 2025 after the FDA declared the shortage over — it's now a brand-focused marketplace, so the old ~$99 compounded price is gone
- The subscription and the medication are two separate charges — read both before you budget
- A real video visit is included, more hands-on than a purely asynchronous signup
Pricing
Prices re-verified
Brand semaglutide
$149
Plan
Wegovy pill (oral semaglutide), lower doses
Listed as 'from as little as $149/mo' for lower doses; the medication is billed separately from the Sesame subscription.
Brand semaglutide
$349
Plan
Ozempic (brand-name, est. cash pay)
Around $349/mo at Costco Pharmacy per Sesame's own hub; paying cash for brand-name runs higher.
Brand tirzepatide
$349
Plan
Zepbound vials
$349–$499/mo depending on dose, per Sesame's weight-loss hub.
Ask your account administrator whether the exact charges qualify for HSA/FSA reimbursement and what itemized receipts you need. Prices reflect what Sesame disclosed publicly at our last review and change often; confirm the current number on Sesame's site.
What we like
- A real video visit with a licensed clinician, plus labs and messaging in the subscription
- FDA-approved brand-name options (Wegovy pill, Ozempic, Zepbound) with the manufacturer's own label
- Transparent cash-pay marketplace pricing — no insurance needed, HSA/FSA commonly accepted
- Nationwide, from an established and well-known marketplace
The caveats
- No longer offers low-cost compounded GLP-1s — it exited that market in 2025
- The subscription and the medication are billed separately, so the true monthly cost is higher than the headline
- Brand-name medication runs $149–$499/mo, well above the flat compounded programs
- No specific postpartum, breastfeeding, or PCOS focus
First, a correction you'll be glad you read
If you've seen Sesame reviewed as the place to get $99 compounded semaglutide, that information is out of date, and it's the most important thing to fix before you sign up anywhere. After the FDA declared the semaglutide shortage over in early 2025, compounding pharmacies had to stop making compounded semaglutide, and Sesame stepped out of that market. Today it's a brand-name marketplace: the Wegovy pill starts around /mo at the lowest doses, and options like Ozempic and Zepbound cost more. So the rock-bottom compounded price that made Sesame famous simply isn't there anymore.
What Sesame actually is now — and why it can still be a good fit
Don't take that as a knock. Sesame is a well-established, transparent cash-pay marketplace, and what it offers now has real appeal for someone starting out: an actual video visit with a licensed clinician, labs and messaging included in a 'Success by Sesame' subscription (from $59/mo on an annual plan), plus FDA-approved brand-name medication that comes with the manufacturer's own label. That's more hand-holding than a fill-out-a-form-and-wait service, and brand-name medication is the cleanest thing to hand your OB-GYN when you're thinking about timing.
The real numbers by medication
It's worth seeing the full figures before picking a medication. The Wegovy pill starts around $149/mo at the lowest doses. Ozempic runs about $349/mo at Costco Pharmacy, per Sesame's own hub. Zepbound vials run $349 to $499/mo depending on dose. And if the annual $59/mo subscription cycle doesn't work for you, there's a shorter 28-day version around $99/mo. None of these figures include the medication itself — they're the subscription and clinician access alone.
The math to do before you commit
The one place to be careful is the bill. Sesame's subscription and the medication are two separate charges — the membership buys you the visits and the follow-up, and the brand-name drug is billed on top of it. So your real monthly cost is the subscription plus the medication, not the tidy $59 headline. Brand-name GLP-1s, even at Sesame's negotiated cash prices, land well above a flat-price compounded plan. Add up both lines honestly, and check whether your HSA/FSA card can cover them.
The bottom line
Sesame is a reliable, clinician-led way to get brand-name GLP-1 medication without insurance — just go in knowing it's no longer the cheap compounded option it once was. If a real video visit and brand-name medication matter to you more than the lowest price, it's a solid choice. If you are considering a compounded preparation, read CoreAge Rx to compare prices and request the exact product and terms before paying — and our ranking of the best options for moms puts the whole picture side by side.
The bottom line
Best for: Moms who'd rather have FDA-approved brand-name medication and a real clinical visit than the lowest compounded price, and who don't mind separate subscription and medication bills.
Other providers to compare
Providers to compare, with referral partners listed first. Placement and score are separate; some links earn MamaGLP a commission.
- Meet CoreAge Rx
Compounded semaglutide and tirzepatide with advertised flat prices; clarify the offer and renewal rules before paying.
- Meet Enhance MD
$249/mo semaglutide, $329/mo tirzepatide with no commitment ($212 and $280 on the 12-month plan), a named Medical Director and a real video visit before anything is prescribed.
- Meet Gala Health
$179/mo for either medication, flat across doses, with a genuinely gentle microdose tier — if you can live with an annual plan and a pharmacy it will not name.
Keep comparing Sesame
Head-to-heads and alternatives
Ranked boards
- Best GLP-1 for moms — a gentle first step
- Best GLP-1 for women — PCOS, cycles, perimenopause
- Best GLP-1 for first-timers (easiest to start)
- Most affordable GLP-1 with honest, clear pricing
- Best semaglutide for mothers — price and practicality
- Best semaglutide for women — compounded vs brand
- Best semaglutide for young moms — postpartum and budget
- Best tirzepatide for mothers — is it worth the extra
- Best tirzepatide for women — PCOS and insulin resistance
- Best GLP-1 with bilingual / Spanish-language support
Sesame, answered
- Does Sesame still sell compounded semaglutide at $99?
- No — and this is an important correction if you've seen that number floating around. After the FDA declared the semaglutide shortage over in early 2025, compounding pharmacies had to stop making compounded semaglutide, and Sesame exited that market. Today it's a brand-focused marketplace: the Wegovy pill starts around $149/mo at the lowest doses, Zepbound runs $349–$499, and there's a separate 'Success by Sesame' subscription (from $59/mo on an annual plan) for the visits and follow-up.
- Is Sesame a good, calm first step for a mom?
- It can be a solid, transparent option — you get a real video visit with a licensed clinician, labs and messaging included in the subscription, and brand-name medication with the manufacturer's own label. The trade-off versus a flat-price compounded program is cost and moving parts: the membership and the medication are billed separately, so add both up honestly. For the simplest single flat number, our #1 pick is friendlier to the budget.
- Does Sesame need my insurance?
- No — Sesame is a cash-pay marketplace built for people paying out of pocket, which is part of the appeal. Just remember that the medication cost is on top of the subscription, and brand-name GLP-1s (even at Sesame's negotiated cash prices) land well above the compounded options. HSA/FSA cards are usually accepted; check your plan.
- Can I use Sesame while breastfeeding?
- Evidence is insufficient to establish that a GLP-1 is safe during breastfeeding. Labels differ by formulation: Wegovy tablets advise against breastfeeding because of the absorption ingredient SNAC; Wegovy injection and Zepbound labeling ask clinicians to weigh maternal need, breastfeeding benefits and possible infant risks. This does not establish that injections are safe. Discuss the exact medication and the program's eligibility policy with your clinician and your baby's pediatrician before deciding; our GLP-1 and breastfeeding guide explains the distinction.
Prices, states and verification reflect what Sesame disclosed publicly at our last review; the Mama-Match Score is our editorial judgment under the published methodology. This is background information, not medical advice. Pregnancy and breastfeeding guidance depends on the drug and formulation. Read the current Wegovy label and Zepbound label. See our medical disclaimer and how we're funded.