Mama-Match
Sesame review
A cash-pay medical marketplace with some of the lowest posted GLP-1 prices anywhere — you're booking a clinician yourself, which is cheap and flexible but less hand-held.
- HSA / FSA-eligible
- Independently scored
- No insurance needed
Referral link, walled off from the score
Research checked by Beatriz Lang, our evidence reviewer — a former pharma-industry analyst (a disclosed pen name), not a clinician who treats you. What follows is friendly information, never medical advice.
Gentler first steps than Sesame
The top-scoring providers we'd point a friend to — CoreAge Rx leads our ranking. Some of these links earn MamaGLP a referral fee; it never changes the order.
- Meet CoreAge RxCoreAge RxOur #1 pick
The gentlest place for a first-timer to land: one flat, no-surprise monthly price, both medicines on a single account, and an intake that walks you through it instead of quizzing you into a corner.
- Meet Trimi Health
The budget-first pick with a soft landing: some of the lowest flat, all-in compounded pricing we've found, nationwide — as long as you read the yearly-prepay fine print behind that eye-catching $99.
- Meet Gala Health
A flat $179 for either medicine with a genuinely gentle microdosing tier — a reasonable, all-doses-included option if you can live with a yearly plan and a pharmacy it doesn't name.
Sesame at a glance
- Semaglutide
- $99/mo
- Tirzepatide
- $199/mo
- Coverage
- All 50 states
- Brand-name
- Compounded only
How we scored Sesame
Each factor is scored from Sesame's real pricing, disclosures and support, then combined into the 83/100 Mama-Match Score by the same weighted six-factor framework we apply to every provider — never nudged by whether a provider pays us.
A reasonable signup, if a little more standard than hand-held.
Among the most honest, predictable prices we track — the number you see is the number you pay.
Reasonable clinician involvement, though some program details aren't public.
Available in all 50 states, so where you live isn't a barrier.
Support is thin once the prescription ships.
Cancellation is workable but not frictionless.
How we checked this review
- Last checked
- February 2026
- Confidence
- medium
- Primary source
- sesamecare.com
Pricing
Prices re-verified
| Medication | Plan | Monthly |
|---|---|---|
| Compounded semaglutide | Compounded semaglutide | $99 |
| Compounded tirzepatide | Compounded tirzepatide | $199 |
HSA/FSA is commonly accepted for GLP-1 telehealth — check your plan. Prices reflect Sesame's public disclosures at last review and change often; confirm the current number on Sesame's own site.
What we like
- Among the lowest posted cash prices for compounded semaglutide
- Transparent, upfront marketplace pricing — no membership to decode
- Nationwide, with flexible clinician booking on your schedule
The caveats
- You drive the process — less of a warm, guided first-timer experience
- Care can feel piecemeal since it's a marketplace, not one continuous program
Sesame for moms: our verdict
A cash-pay medical marketplace with some of the lowest posted GLP-1 prices anywhere — you're booking a clinician yourself, which is cheap and flexible but less hand-held. It runs about $99/month — toward the affordable end of what we track.
We weigh Sesame the way moms actually have to: not just the monthly cost, but timing around pregnancy and breastfeeding and an honest, upfront price — the parts a generic weight-loss review skips.
What Sesame actually costs
- Compounded semaglutide — Compounded semaglutide: $99/mo
- Compounded tirzepatide — Compounded tirzepatide: $199/mo
That sits below the roughly $162 median ongoing price across the providers we track for moms — a real cost advantage.
The medications Sesame prescribes
Sesame prescribes semaglutide and tirzepatide — the two molecules with the strongest published weight-loss outcomes, and having both on one account matters when insulin resistance (common with PCOS and after gestational diabetes) makes tirzepatide the better-suited option. These are compounded formulations from a licensed pharmacy — the reason the price stays down — but compounded GLP-1s aren't FDA-approved finished products the way Wegovy and Zepbound are.
Where Sesame fits — and where it doesn't — for moms
A good fit if…
- you want a real clinician reading your history around timing around pregnancy and breastfeeding, not an auto-approving quiz.
- the monthly cost is a real barrier and you want a low, predictable number.
- you may need to move between semaglutide and tirzepatide as your body and hormones change.
- uninterrupted nationwide access matters — a move for family shouldn't interrupt care.
Look elsewhere if…
- you specifically want an FDA-approved brand pen with its own pregnancy and lactation labeling.
- you'd rather a prescriber talk through timing around timing around pregnancy and breastfeeding — that's what our #1 pick, CoreAge Rx, is built for.
Trust, safety, and oversight
Our confidence is moderate — the core facts check out, but some details (per-state availability, program mechanics) aren't fully public. As with any compounded GLP-1, the most useful thing moms can do is confirm which licensed pharmacy fills the prescription and what's in the formulation — we explain how we weigh oversight in our scoring methodology.
A standing caveat for moms: GLP-1 medications aren't established as safe during pregnancy or breastfeeding, and every label advises against use. Nothing here changes that — plan the timing with your own clinician.
The bottom line
Sesame is a genuine value play — weigh it on timing around pregnancy and breastfeeding and an honest, upfront price against the alternatives below. For most moms, CoreAge Rx remains the stronger all-round fit — see why it tops our ranking.
The bottom line
Best for: Confident, budget-first moms who are comfortable steering their own care.
Keep comparing Sesame
Head-to-head & alternatives
Sesame, answered
- How much does Sesame cost?
- As last checked, Sesame's compounded pricing starts around $99/month ($99/mo semaglutide, $199/mo tirzepatide). Confirm the current, all-in price on Sesame's own site before you commit.
- Is Sesame safe to use while breastfeeding?
- Here's the honest answer: no GLP-1 — compounded or brand — is established as safe during pregnancy or breastfeeding, and the labels advise against use; Sesame is no exception. Plan any GLP-1 for after weaning, and talk the timing through with your own clinician.
- Does Sesame offer both semaglutide and tirzepatide?
- Yes — Sesame offers both. Tirzepatide's dual action is often preferred where insulin resistance drives weight, which matters for PCOS and after gestational diabetes.
- Where does Sesame land in your ranking?
- Sesame scores 83/100 on our Mama-Match Score (rank #9), which weights six things that matter for a first-timer. Our #1 pick, CoreAge Rx, leads the ranking — see how they compare.
Pricing, states and verification reflect Sesame's public disclosures at last review; the Mama-Match Score is our editorial judgment per the published methodology. This is friendly background reading, not medical advice — GLP-1 medications are not established as safe in pregnancy or breastfeeding. See our medical disclaimer and how we're funded.