Head to head for first-timers
Sesame vs Synergy Rx
Sesame and Synergy Rx both offer GLP-1 telehealth, but they make different trade-offs on how gentle the start is, honest pricing, real support and access. Here they are side by side on the Mama-Match Score — our first-timer rubric.
Sesame
Higher scoreRank #4 for first-timers · Grade B
Mama-Match
Best for: Moms who'd rather have FDA-approved brand-name medication and a real clinical visit than the lowest compounded price, and who don't mind separate subscription and medication bills.
Visit SesameSynergy Rx
Rank #19 for first-timers · Grade C
Mama-Match
Best for: People comparing formats who obtain complete purchase terms before payment.
Visit Synergy RxThe verdict for a first step
Sesame edges out Synergy Rx on the Mama-Match Score, 83 to 78 (B vs C). Moms who'd rather have FDA-approved brand-name medication and a real clinical visit than the lowest compounded price, and who don't mind separate subscription and medication bills.
Synergy Rx is still a genuine option — injection, compounded tablet and brand menu with public amounts; supply and renewal need confirmation. Weigh the six first-timer factors below against your own priorities.
Side by side on all six factors
Both providers judged on the same first-timer rubric — the higher side on each factor is marked. See the methodology.
Price, access and features
| Detail | Sesame | Synergy Rx |
|---|---|---|
| Mama-Match Score | 83/100 · B | 78/100 · C |
| Overall rank | #4 | #19 |
| Semaglutide | Brand only (Wegovy pill from ~$149/mo) | Total varies: starting amount and period unconfirmed |
| Tirzepatide | Brand only (Zepbound ~$349–$499/mo) | Total varies: starting amount and period unconfirmed |
| Coverage | All 50 states | Confirm availability with support under the terms |
| Brand-name access | Yes | Yes |
| Oral / sublingual | Yes | Yes |
Mama-Match
Sesame
Rank #4 · Grade B
What we like
- A real video visit with a licensed clinician, plus labs and messaging in the subscription
- FDA-approved brand-name options (Wegovy pill, Ozempic, Zepbound) with the manufacturer's own label
- Transparent cash-pay marketplace pricing — no insurance needed, HSA/FSA commonly accepted
The caveats
- No longer offers low-cost compounded GLP-1s — it exited that market in 2025
- The subscription and the medication are billed separately, so the true monthly cost is higher than the headline
- Brand-name medication runs $149–$499/mo, well above the flat compounded programs
Mama-Match
Synergy Rx
Rank #19 · Grade C
What we like
- Publishes product amounts in its catalog
- Names a clinical group and pharmacy partners
- Distinguishes branded and compounded options
The caveats
- Starting figures do not establish supply or billing interval
- Completed consultations are nonrefundable under terms
- Compounded tablets are not equivalent to approved injections
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes a Mama-Match Score. Prices, states and verification reflect what each provider disclosed publicly at our last review; the Mama-Match Score is our editorial judgment under the methodology. Prices change — confirm them on each provider’s site. Not medical advice; see our disclosure.
More head-to-heads
Keep comparing Sesame and Synergy Rx with the other providers we review for women.
- Sesame vs Form Health
- Sesame vs Hers
- Sesame vs CoreAge Rx
- Synergy Rx vs Breeze Meds
- Synergy Rx vs CoreAge Rx
Or browse the full comparison hub.